Endocrine Abstracts

Introduction-objective: Fas-mediated thyroid cell apoptosis is differentially regulated in autoimmune thyroid disease (AITD) being up-regulated in Hashimoto’s thyroiditis (HT) and down-regulated in Graves’ disease (GD). The soluble form of Fas (sFas), lacking the transmembrane domain due to alternative splicing may inhibit apoptosis by binding to Fas ligand. In this preliminary study we examined whether sFas is also differentially expressed in patients with AITD....

Introduction: Patients with adrenal adenomas appear to exhibit an appreciable prevalence of autonomous aldosterone secretion (AAS). Our aim was to evaluate the anti-hypertensive effect of targeted therapy with mineralocorticoid receptor (MR) antagonists in AAS patients.Patients and methods: We studied 60 hypertensive patients, 21 males and 39 females, harboring an adrenal adenoma with AAS. All patients were receiving combination of anti-hypertensive trea...